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Tetrahydro pyrrole (THP)

Tetrahydro pyrrole (THP), also known as pyrrolidine, is a five-membered cyclic compound.

Chemical formula C4H9N, CAS number 123-75-1, molecular weight 71.121.
This substance is a colorless to yellow liquid with a density of 0.8±0.1g/cm³, a boiling point of 89.5±8.0℃ (760mmHg), a melting point of -63℃, and a flash point of 2.8±0.0℃. It is miscible with organic solvents such as water, alcohol, ether, and chloroform. It has a pungent odor and tends to turn yellow when exposed to light or moisture. It is somewhat volatile. Tetrahydropyrrole is chemically active and reacts with a variety of organic and inorganic compounds, exhibiting varying reactivity especially under acidic and alkaline conditions.
Tetrahydropyrrole content:
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Applications of Tetrahydropyrrole

1. Pharmaceutical Intermediates

Tetrahydropyrrole is widely used in the pharmaceutical field as an intermediate in the synthesis of various drugs. For example, it is an essential intermediate in the synthesis of antidepressants, antianxiety drugs, and certain cardiovascular drugs. Its unique ring structure provides specific chemical reaction sites, enabling the efficient synthesis of drug molecules.


SN

English Name

Chinese Name

Drug efficacy

1

Buflomedil

丁咯地尔

Cerebrovascular disease medications

2

Dextromoramide tartrate

酒石酸右吗拉胺

Analgesics

3

Procyclidine HCI

丙环定,普环定,卡马特灵

Antiparkinsonian medications

4

Piromidic acid

吡咯米酸

Anti-infective medications

5

Amixetrine

阿米西群

Antispasmodics

6

Bepridil

苄普地尔


7

Prolintane

普罗林坦,丙苯乙吡咯

Stimulants and antidepressants

8

Pyrrocaine

吡咯卡因

Local anesthetics

 

It can also be used as a solvent. For example, tetrahydropyrrole was used as a solvent in the semi-synthesis of the cardiovascular drug simvastatin, with a molar consumption ratio of approximately 1:1.

2. Pesticide Synthesis

In the pesticide field, tetrahydropyrrole is also widely used in the synthesis of various insecticides and herbicides. Its use as an intermediate not only improves the synthesis efficiency of pesticides but also enhances their stability and biological activity, such as Lolopgranule.

3. New Materials Research and Development

The application of tetrahydropyrrole in new materials is also gaining attention. For example, in the synthesis of polymers with unique optical properties, tetrahydropyrrole can serve as a crosslinker or functional monomer, imparting excellent properties to the materials.

4. Catalyst Promoter

In chemical production, tetrahydropyrrole is often used as a catalyst promoter, significantly improving the efficiency and selectivity of catalytic reactions. In particular, in complex chemical reactions, tetrahydropyrrole can effectively reduce reaction temperature and pressure, thereby reducing production costs.


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